Sending automatic replies, e.g. out-of-office notices or other important messages from your mailbox is quite easy with Helpmonks.

First thing is to create a saved reply in your mailbox. You can find the Saved Reply in the Mailbox Settings.

Once you have your saved reply. In the Mailbox Settings, click Workflows and create a new workflow. Set the TRIGGER to 'Trigger for Customers'. 

Under CONDITIONS, you can choose from the given option on which emails would you like the auto-replies to be executed. Please note that if you do not select a condition the workflow will apply to all emails.

Lastly, under ACTIONS select “send a saved reply”.

From here on, every new email will receive your auto-reply. Any given email address will receive your auto-reply no more than once in a 24-hour period. Unless the option to "send a reply each time (ignore the 24 hours rule)" is enabled.

However, if you want to only send it to certain customers or during certain times, set the proper conditions, e.g. “when the email arrives at a certain time”, etc.

Here is a screenshot of a workflow sending an “out-of-office” reply over the weekend.